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Showing posts from April, 2024

PEGylation Introduction

In the development of drug discovery and development, researchers are continually seeking innovative strategies to improve drug efficacy, reduce side effects, and enhance patient outcomes. One such strategy gaining momentum is PEGylation, a process that involves conjugating drugs or therapeutic molecules with polyethylene glycol (PEG) polymers. This article explores the transformative potential of PEGylation in drug discovery applications, shedding light on its mechanisms, benefits, and the role of PEG services in advancing pharmaceutical research. PEGylation   involves covalently attaching PEG polymers to drugs or therapeutic molecules, thereby altering their pharmacokinetic and pharmacodynamic properties. This modification can prolong circulation time, enhance solubility, reduce immunogenicity, and improve the overall therapeutic profile of the drug.   Advantages of PEGylation: Extended Circulation Time: PEGylation shields drugs from rapid clearance by the immune system, all...